Pier Mario Biava | Reprogram Cells2018-12-11T19:37:48+00:00

Caring For Life

Reprogramming cells in a physiological way to bring them back to a healthy state is what I have been studying for a lifetime.

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Welcome to the era of Cells Reprogramming

The mechanism of physiological reprogramming of cells is present in a human organism at its embryonic stage in perfect equilibrium, which is therefore able to rebuild the life cycle of a single cell. Unfortunately while the years pass, this balance gets altered and the cells decay and die due to natural or pathological causes. Now it is possible to reproduce this regeneration mechanism even in adult organisms, counteracting its decay or degeneration thanks to the growth and differentiation factors.

Zebrafish, or Danio rerio, is a freshwater fish which lately has become the most used animal model for laboratory studies in the world, thanks to its particular characteristics. At specific times of the growth of Zebrafish embryos, it is possible to obtain, using sophisticated techniques, an entire epigenetic code capable of reprogramming human cells and differentiating them.

Pier Mario Biava, an occupational doctor, graduated in Medicine at the University of Pavia, specializing first in occupational medicine at the University of Padua and later in hygiene at the University of Trieste. He has been studying the relationship between cancer and cell differentiation for several years: he has isolated stem growth and differentiation factors that can inhibit or slow down the growth of various types of human tumors and, in general, direct the fate of normal and pathological stem cells. This is of a significant importance in the field of prevention and treatment of various types of diseases such as chronic degenerative diseases, as well as in the field of regenerative medicine in renewal and regeneration of tissues. This research can also have positive effects in the field of integrative treatments of stem cell transplants and, in the future, may even replace them.

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Having been a Professor at the School of Specialization in Occupational Medicine in Trieste for many years, he currently works at the Institute of Research and Treatment Multimedica of Milan.
He is the author of over 100 scientific publications and several books such as: ” L’Aggressione Nascosta – Limiti Sanitari di Esposizione ai Rischi ” published by Feltrinelli, ” Complessità e Biologia” published by Bruno Mondadori and ” Il Cancro e la Ricerca del Senso Perduto” published by Springer,” Il Senso Ritrovato “edited by Ervin Laszlo and published by Springer and “Dal segno al simbolo – The manifesto of the new paradigm in medicine” written with Diego Frigoli and Ervin Laszlo and published by Persiani.
He also takes part in the Scientific Committees of several international journals in the field of oncology and epidemiology.

Tasks performed:
Scientific responsible for formation of the occupational health service in South America founded in Quito from 1984 to 1990
Member of the WWF Italia Scientific Committee from 1986 to present (still in office), Vice President WWF Italy 2006 -2009
Member of the CDA Unicredit Foundation from 2002 to 2005 where he leaded planning of all health cooperation interventions in Africa.


“GROWTH AND DIFFERENTIATION FACTORS have a significant biological activity, which is essential for maintaining cellular health. Some proteins are important for the life of mitochondria, others have the function of regulating cell cycle, immunity response and so on. Therefore the biological molecules of ROE EXTRACT are essential for maintaining cells in our body in optimal health state and revitalizing tissues, minimizing aging phenomena.”

It has been shown that the differentiation factors of the stem cells taken from the egg of Zebrafish, which has more than 90% of proteins in common with the human ones, are able to differentiate the cell cycle and reprogram cells in a physiological way (without genetic manipulation).

Dr. Pier Mario Biava and his team of scientists have shown that specific GROWTH and DIFFERENTIATION FACTORS can increase the life span of cells, preventing the cutting of telomeres and contributing to the synthesis of proteins, which stop the aging of cells.

Dr. Pier Mario Biava on Telomeres:

“Telomeres get shorter each time the cells divide. When the telomere becomes too short, the chromosome reaches a critical length and the cell can no longer replicate. This means that the cell ages and dies. However, GROWTH and DIFFERENTIATION FACTORS can be a very effective tool to promote cellular senescence antagonists in a physiological way. The result is a healthy cell and potentially an inversion of the aging process”

TELOMERS are essential parts of human cells that influence the way we age. Telomeres represent sort of a “cap” of DNA that protects cells from errors during their replication. Over time this hood tends to shorten and lose its protective properties. Thanks to the factors of Zebrafish this problem can be prevented by preserving telomers.


In this documentary you will find many answers both on the nature of mechanisms that mediate the transfer of epigenetic information to DNA: the differentiation factors and on the practical applications of these researches.


The Growth Factors appropriately matched to the differentiation factors prevent cellular senescence and therefore aging



The Growth Factors appropriately matched to the differentiation factors prevent cellular senescence and therefore neuro-degeneration



Differentiation Factors are able to reprogram tumor cells by making them get back to a normal behavior i.e. to a normal phenotype.


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